Baltimore scientists believe they have found a way to improve predict C and finally C for survival in patients with malignant peritoneal mesothelioma (MPM).Peritoneal Mesothelioma is a rare cancer of the lining of the abdominal cavity. Like other forms of mesothelioma caused by asbestos mineral fibers. If it is almost always fatal, people with peritoneal mesothelioma tends to very different reactions to disease.
The researchers attempted to explain the reasons for this variability and the response can grow in the signaling pathways that cancer cells and multiply to determine said. Experiment in tumor samples from 41 patients with mesothelioma, the researchers analyzed the genes expressed by each group of cells. What they have found a significant difference in the chemical signaling for the synthesis of proteins and RNA in the cells.
is overexpressed in a group known signaling pathways phosphoinositide 3-kinase (PI3K) and the objective of monitoring the interaction of the mammalian rapamycin (mTOR). were in cases in which the genes present produced by these channels, the patients with peritoneal mesothelioma who received a median of 24 months.
But in cases where these channels and their corresponding genes were not found, mesothelioma patients have a median survival of 69.5 months. To test his theory that were, these cellular pathways to cancer cell proliferation and prognosis to inhibit the researchers used a chemical to P13K and mTOR signaling pathways in the cell samples. They found that when these channels are inhibited cell signaling and cell proliferation were significantly reduced.
The study was conducted by the Department of Surgical Oncology at the University of Maryland School of Medicine, Baltimore conducted and published in an upcoming issue of Cancer.
